Modulators of Notch signaling

Vladislav M. Panin, Kenneth D. Irvine

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


In addition to the core components of the Notch pathway, a number of proteins have been identified that exert positive or negative influences on Notch signaling. These include extracellular modulators, which may influence binding or activation of Notch by its ligands, cytoplasmic modulators, which presumably influence signal transduction steps after receptor activation, and nuclear modulators, which may influence the transcriptional activity of a Notch - CSL protein complex. Many of the cytoplasmic and nuclear modulators appear to bind directly to discrete domains within the intracellular domain of Notch. Genetic studies indicate that distinct modulators are deployed during distinct modes of Notch signaling.

Original languageEnglish (US)
Pages (from-to)609-617
Number of pages9
JournalSeminars in Cell and Developmental Biology
Issue number6
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology


  • Development
  • Lin-12
  • Modulator
  • Notch
  • Signaling


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