Molecular and cellular pathology of Meniere's disease

P. A. Wackym, I. Sando

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The etiopathogenesis of Meniere's disease has remained controversial since the early 1900s. Many investigators have studied the molecular and cellular pathology of the inner ear in patients with this disorder. Three basic pathologic mechanisms have emerged; fibrosis of the endolymphatic sac and vestibular epithelia, altered glycoprotein metabolism, and immune- mediated inner ear disease. This article reviews the current understanding of these three basic pathologic processes.

Original languageEnglish (US)
Pages (from-to)947-960
Number of pages14
JournalOtolaryngologic Clinics of North America
Issue number6
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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