Molecular aptamers for drug delivery

Weihong Tan, Hui Wang, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoyong Yang, Ronghua Yang, Chen Liu

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

The active targeting of drugs in a cell-, tissue- or disease-specific manner represents a potentially powerful technology with widespread applications in medicine, including the treatment of cancers. Aptamers have properties such as high affinity and specificity for targets, easy chemical synthesis and modification, and rapid tissue penetration. They have become attractive molecules in diagnostics and therapeutics rivaling and, in some cases, surpassing other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes.

Original languageEnglish (US)
Pages (from-to)634-640
Number of pages7
JournalTrends in Biotechnology
Volume29
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

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