Molecular characteristics of kappa-selenocarrageenan and application in green synthesis of silver nanoparticles

Weiping Jin, Yiran Yu, Wenfu Hou, Guozhen Wang, Zhenzhou Zhu, Jingren He, Shuiyuan Cheng, Qingrong Huang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Selenium is an essential trace element in human body, and kappa-selenocarrageenan (Se-car) is an organic source of selenium supplement. To further utilize Se-car in food packaging, biotherapy or biosensor, the molecular information of Se-car was characterized here and multi-functional Ag NPs synthesized by Se-car were fabricated. Results of GPC-MALLS, FTIR, potentiometric titration, and intrinsic viscosity showed that Se-car was polymerized by nearly 22 basic units of disaccharide. Sixty-four percentage of sulfated groups (SO4 2−) in carrageenan was replaced by selenium acid (SeO3 2−), which belonged to weak acid resulting from a gradually decrease of ζ-potential with acidity process to pH 1.0. Besides, the capacity of biosynthesis silver nanoparticles (Ag NPs) by Se-car was studied and it made a comparison with κ-carrageenan. Results exhibited that Se-car could serve as an efficient reducing and capping agent for Ag NPs fabrication (remarked as Se-car@Ag). The kapp of Se-car@Ag NPs for catalyzing 4-NP degradation was 2.14 × 10−2 s−1. Antibacterial test revealed Se-car@Ag had an ability to inhibit the growth of Escherichia coli and Staphylococcus aureus. To combine the selenium health benefit and functional metal nanoparticles, Se-car@Ag might have potential applications in multiple areas like medicine, disease diagnostic, and drug delivery.

Original languageEnglish (US)
Pages (from-to)529-537
Number of pages9
JournalInternational Journal of Biological Macromolecules
StatePublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)


  • Anti-microbial activity
  • Kappa-selenocarrageenan
  • Molecular structure
  • Silver nanoparticles
  • κ-Carrageenan


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