Molecular characterization of an early invasive staphylococcus epidermidis prosthetic joint infection

Marnie E. Rosenthal, Lisa L. Dever, Calin S. Moucha, Kalyan D. Chavda, Michael Otto, Barry N. Kreiswirth

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Historically regarded as a skin commensal, Staphylococcus epidermidis has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant S. aureus and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (α-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and β-type phenol-soluble modulins).

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalMicrobial Drug Resistance
Issue number3
StatePublished - Aug 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)


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