Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection

Preeti Pancholi; Steven Park; David Perlin; Christine Kubin; Phyllis Della-Latta

doi:10.1128/JCM.42.12.5938-5939.2004

Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection

Preeti Pancholi, Steven Park, David Perlin, Christine Kubin, Phyllis Della-Latta

New Jersey Medical School (NJMS), Public Health Research Institute Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Ocular yeast infections in diabetics are a therapeutic challenge. Drag resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.

Original language	English (US)
Pages (from-to)	5938-5939
Number of pages	2
Journal	Journal of clinical microbiology
Volume	42
Issue number	12
DOIs	https://doi.org/10.1128/JCM.42.12.5938-5939.2004
State	Published - Dec 2004

All Science Journal Classification (ASJC) codes

Microbiology (medical)

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abstract = "Ocular yeast infections in diabetics are a therapeutic challenge. Drag resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.",

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