Molecular design and delivery of antisense oligonucleotides

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An account is given on work towards overcoming two of the barriers to antisense effectiveness. The first work concerns the development of molecular targeting strategies for the delivery of high concentrations of active oligonucleotide to a specific cell type. Second, given the variable and often poor affinity of antisense sequences, strategies for the rational design of high affinity antisense sequences are detailed.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages677-678
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - 1999
Externally publishedYes
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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