Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments

G. Kessler-Icekson, Y. Barhum, H. Schlesinger, J. Shohat, H. Sharma, W. Schaper, S. Vatner, R. Reneman, J. Janicki, H. E.D.J. Ter Keurs, J. Solaro

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Abstract

Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the 'fetal' genes, ANP, α-skeletal actin (α-skA), and β myosin heavy chain (β-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the 'fetal gene program'.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalAdvances in experimental medicine and biology
Volume382
StatePublished - Jan 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kessler-Icekson, G., Barhum, Y., Schlesinger, H., Shohat, J., Sharma, H., Schaper, W., Vatner, S., Reneman, R., Janicki, J., Ter Keurs, H. E. D. J., & Solaro, J. (1995). Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments. Advances in experimental medicine and biology, 382, 195-203.