Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments

G. Kessler-Icekson, Y. Barhum, H. Schlesinger, J. Shohat, H. Sharma, W. Schaper, S. Vatner, R. Reneman, J. Janicki, H. E.D.J. Ter Keurs, J. Solaro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the 'fetal' genes, ANP, α-skeletal actin (α-skA), and β myosin heavy chain (β-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the 'fetal gene program'.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalAdvances in experimental medicine and biology
Volume382
StatePublished - Jan 1 1995

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Cardiomegaly
Inbred SHR Rats
Antihypertensive Agents
Rats
Genes
Myosin Heavy Chains
Blood pressure
Atrial Natriuretic Factor
Actins
Young Adult
Blood Pressure
Hypertension
Messenger RNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kessler-Icekson, G., Barhum, Y., Schlesinger, H., Shohat, J., Sharma, H., Schaper, W., ... Solaro, J. (1995). Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments. Advances in experimental medicine and biology, 382, 195-203.
Kessler-Icekson, G. ; Barhum, Y. ; Schlesinger, H. ; Shohat, J. ; Sharma, H. ; Schaper, W. ; Vatner, S. ; Reneman, R. ; Janicki, J. ; Ter Keurs, H. E.D.J. ; Solaro, J. / Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments. In: Advances in experimental medicine and biology. 1995 ; Vol. 382. pp. 195-203.
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Kessler-Icekson, G, Barhum, Y, Schlesinger, H, Shohat, J, Sharma, H, Schaper, W, Vatner, S, Reneman, R, Janicki, J, Ter Keurs, HEDJ & Solaro, J 1995, 'Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments', Advances in experimental medicine and biology, vol. 382, pp. 195-203.

Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments. / Kessler-Icekson, G.; Barhum, Y.; Schlesinger, H.; Shohat, J.; Sharma, H.; Schaper, W.; Vatner, S.; Reneman, R.; Janicki, J.; Ter Keurs, H. E.D.J.; Solaro, J.

In: Advances in experimental medicine and biology, Vol. 382, 01.01.1995, p. 195-203.

Research output: Contribution to journalArticle

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AU - Sharma, H.

AU - Schaper, W.

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AU - Solaro, J.

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