Molecular markers in head and neck squamous cell carcinoma: Their biological function and prognostic significance

B. D. Smith, B. G. Haffty, C. T. Sasaki

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume110
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Keywords

  • Head and neck cancer
  • Molecular markers
  • Prognostic factors

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