Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi; Ilio Vitale; Stuart A. Aaronson; John M. Abrams; Dieter Adam; Patrizia Agostinis; Emad S. Alnemri; Lucia Altucci; Ivano Amelio; David W. Andrews; Margherita Annicchiarico-Petruzzelli; Alexey V. Antonov; Eli Arama; Eric H. Baehrecke; Nickolai A. Barlev; Nicolas G. Bazan; Francesca Bernassola; Mathieu J.M. Bertrand; Katiuscia Bianchi; Mikhail V. Blagosklonny; Klas Blomgren; Christoph Borner; Patricia Boya; Catherine Brenner; Michelangelo Campanella; Eleonora Candi; Didac Carmona-Gutierrez; Francesco Cecconi; Francis K.M. Chan; Navdeep S. Chandel; Emily H. Cheng; Jerry E. Chipuk; John A. Cidlowski; Aaron Ciechanover; Gerald M. Cohen; Marcus Conrad; Juan R. Cubillos-Ruiz; Peter E. Czabotar; Vincenzo D'Angiolella; Ted M. Dawson; Valina L. Dawson; Vincenzo De Laurenzi; Ruggero De Maria; Klaus Michael Debatin; Ralph J. Deberardinis; Mohanish Deshmukh; Nicola Di Daniele; Francesco Di Virgilio; Vishva M. Dixit; Scott J. Dixon; Colin S. Duckett; Brian D. Dynlacht; Wafik S. El-Deiry; John W. Elrod; Gian Maria Fimia; Simone Fulda; Ana J. García-Sáez; Abhishek D. Garg; Carmen Garrido; Evripidis Gavathiotis; Pierre Golstein; Eyal Gottlieb; Douglas R. Green; Lloyd A. Greene; Hinrich Gronemeyer; Atan Gross; Gyorgy Hajnoczky; J. Marie Hardwick; Isaac S. Harris; Michael O. Hengartner; Claudio Hetz; Hidenori Ichijo; Marja Jäättelä; Bertrand Joseph; Philipp J. Jost; Philippe P. Juin; William J. Kaiser; Michael Karin; Thomas Kaufmann; Oliver Kepp; Adi Kimchi; Richard N. Kitsis; Daniel J. Klionsky; Richard A. Knight; Sharad Kumar; Sam W. Lee; John J. Lemasters; Beth Levine; Andreas Linkermann; Stuart A. Lipton; Richard A. Lockshin; Carlos López-Otín; Scott W. Lowe; Tom Luedde; Enrico Lugli; Marion MacFarlane; Frank Madeo; Michal Malewicz; Walter Malorni; Gwenola Manic; Jean Christophe Marine; Seamus J. Martin; Jean Claude Martinou; Jan Paul Medema; Patrick Mehlen; Pascal Meier; Sonia Melino; Edward A. Miao; Jeffery D. Molkentin; Ute M. Moll; Cristina Muñoz-Pinedo; Shigekazu Nagata; Gabriel Nuñez; Andrew Oberst; Moshe Oren; Michael Overholtzer; Michele Pagano; Theocharis Panaretakis; Manolis Pasparakis; Josef M. Penninger; David M. Pereira; Shazib Pervaiz; Marcus E. Peter; Mauro Piacentini; Paolo Pinton; Jochen H.M. Prehn; Hamsa Puthalakath; Gabriel A. Rabinovich; Markus Rehm; Rosario Rizzuto; Cecilia M.P. Rodrigues; David C. Rubinsztein; Thomas Rudel; Kevin M. Ryan; Emre Sayan; Luca Scorrano; Feng Shao; Yufang Shi; John Silke; Hans Uwe Simon; Antonella Sistigu; Brent R. Stockwell; Andreas Strasser; Gyorgy Szabadkai; Stephen W.G. Tait; Daolin Tang; Nektarios Tavernarakis; Andrew Thorburn; Yoshihide Tsujimoto; Boris Turk; Tom Vanden Berghe; Peter Vandenabeele; Matthew G. Vander Heiden; Andreas Villunger; Herbert W. Virgin; Karen H. Vousden; Domagoj Vucic; Erwin F. Wagner; Henning Walczak; David Wallach; Ying Wang; James A. Wells; Will Wood; Junying Yuan; Zahra Zakeri; Boris Zhivotovsky; Laurence Zitvogel; Gerry Melino; Guido Kroemer

doi:10.1038/s41418-017-0012-4

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V. Antonov, Eli Arama, Eric H. Baehrecke, Nickolai A. Barlev, Nicolas G. Bazan, Francesca Bernassola, Mathieu J.M. Bertrand, Katiuscia Bianchi, Mikhail V. BlagosklonnyKlas Blomgren, Christoph Borner, Patricia Boya, Catherine Brenner, Michelangelo Campanella, Eleonora Candi, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K.M. Chan, Navdeep S. Chandel, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gerald M. Cohen, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Ted M. Dawson, Valina L. Dawson, Vincenzo De Laurenzi, Ruggero De Maria, Klaus Michael Debatin, Ralph J. Deberardinis, Mohanish Deshmukh, Nicola Di Daniele, Francesco Di Virgilio, Vishva M. Dixit, Scott J. Dixon, Colin S. Duckett, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Gian Maria Fimia, Simone Fulda, Ana J. García-Sáez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Pierre Golstein, Eyal Gottlieb, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Atan Gross, Gyorgy Hajnoczky, J. Marie Hardwick, Isaac S. Harris, Michael O. Hengartner, Claudio Hetz, Hidenori Ichijo, Marja Jäättelä, Bertrand Joseph, Philipp J. Jost, Philippe P. Juin, William J. Kaiser, Michael Karin, Thomas Kaufmann, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Richard A. Knight, Sharad Kumar, Sam W. Lee, John J. Lemasters, Beth Levine, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Scott W. Lowe, Tom Luedde, Enrico Lugli, Marion MacFarlane, Frank Madeo, Michal Malewicz, Walter Malorni, Gwenola Manic, Jean Christophe Marine, Seamus J. Martin, Jean Claude Martinou, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Sonia Melino, Edward A. Miao, Jeffery D. Molkentin, Ute M. Moll, Cristina Muñoz-Pinedo, Shigekazu Nagata, Gabriel Nuñez, Andrew Oberst, Moshe Oren, Michael Overholtzer, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Mauro Piacentini, Paolo Pinton, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Markus Rehm, Rosario Rizzuto, Cecilia M.P. Rodrigues, David C. Rubinsztein, Thomas Rudel, Kevin M. Ryan, Emre Sayan, Luca Scorrano, Feng Shao, Yufang Shi, John Silke, Hans Uwe Simon, Antonella Sistigu, Brent R. Stockwell, Andreas Strasser, Gyorgy Szabadkai, Stephen W.G. Tait, Daolin Tang, Nektarios Tavernarakis, Andrew Thorburn, Yoshihide Tsujimoto, Boris Turk, Tom Vanden Berghe, Peter Vandenabeele, Matthew G. Vander Heiden, Andreas Villunger, Herbert W. Virgin, Karen H. Vousden, Domagoj Vucic, Erwin F. Wagner, Henning Walczak, David Wallach, Ying Wang, James A. Wells, Will Wood, Junying Yuan, Zahra Zakeri, Boris Zhivotovsky, Laurence Zitvogel, Gerry Melino, Guido Kroemer

Robert Wood Johnson Medical School (RWJMS), Child Health Institute of New Jersey (CHINJ)

Research output: Contribution to journal › Review article › peer-review

2690 Scopus citations

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Original language	English (US)
Pages (from-to)	486-541
Number of pages	56
Journal	Cell Death and Differentiation
Volume	25
Issue number	3
DOIs	https://doi.org/10.1038/s41418-017-0012-4
State	Published - Mar 1 2018

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Access to Document

10.1038/s41418-017-0012-4

Cite this

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., ... Kroemer, G. (2018). Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), 486-541. https://doi.org/10.1038/s41418-017-0012-4

@article{72d0bdfb97a74a909fa81e666b67910d,

title = "Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018",

abstract = "Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.",

author = "Lorenzo Galluzzi and Ilio Vitale and Aaronson, {Stuart A.} and Abrams, {John M.} and Dieter Adam and Patrizia Agostinis and Alnemri, {Emad S.} and Lucia Altucci and Ivano Amelio and Andrews, {David W.} and Margherita Annicchiarico-Petruzzelli and Antonov, {Alexey V.} and Eli Arama and Baehrecke, {Eric H.} and Barlev, {Nickolai A.} and Bazan, {Nicolas G.} and Francesca Bernassola and Bertrand, {Mathieu J.M.} and Katiuscia Bianchi and Blagosklonny, {Mikhail V.} and Klas Blomgren and Christoph Borner and Patricia Boya and Catherine Brenner and Michelangelo Campanella and Eleonora Candi and Didac Carmona-Gutierrez and Francesco Cecconi and Chan, {Francis K.M.} and Chandel, {Navdeep S.} and Cheng, {Emily H.} and Chipuk, {Jerry E.} and Cidlowski, {John A.} and Aaron Ciechanover and Cohen, {Gerald M.} and Marcus Conrad and Cubillos-Ruiz, {Juan R.} and Czabotar, {Peter E.} and Vincenzo D'Angiolella and Dawson, {Ted M.} and Dawson, {Valina L.} and {De Laurenzi}, Vincenzo and {De Maria}, Ruggero and Debatin, {Klaus Michael} and Deberardinis, {Ralph J.} and Mohanish Deshmukh and {Di Daniele}, Nicola and {Di Virgilio}, Francesco and Dixit, {Vishva M.} and Dixon, {Scott J.} and Duckett, {Colin S.} and Dynlacht, {Brian D.} and El-Deiry, {Wafik S.} and Elrod, {John W.} and Fimia, {Gian Maria} and Simone Fulda and Garc{\'i}a-S{\'a}ez, {Ana J.} and Garg, {Abhishek D.} and Carmen Garrido and Evripidis Gavathiotis and Pierre Golstein and Eyal Gottlieb and Green, {Douglas R.} and Greene, {Lloyd A.} and Hinrich Gronemeyer and Atan Gross and Gyorgy Hajnoczky and Hardwick, {J. Marie} and Harris, {Isaac S.} and Hengartner, {Michael O.} and Claudio Hetz and Hidenori Ichijo and Marja J{\"a}{\"a}ttel{\"a} and Bertrand Joseph and Jost, {Philipp J.} and Juin, {Philippe P.} and Kaiser, {William J.} and Michael Karin and Thomas Kaufmann and Oliver Kepp and Adi Kimchi and Kitsis, {Richard N.} and Klionsky, {Daniel J.} and Knight, {Richard A.} and Sharad Kumar and Lee, {Sam W.} and Lemasters, {John J.} and Beth Levine and Andreas Linkermann and Lipton, {Stuart A.} and Lockshin, {Richard A.} and Carlos L{\'o}pez-Ot{\'i}n and Lowe, {Scott W.} and Tom Luedde and Enrico Lugli and Marion MacFarlane and Frank Madeo and Michal Malewicz and Walter Malorni and Gwenola Manic and Marine, {Jean Christophe} and Martin, {Seamus J.} and Martinou, {Jean Claude} and Medema, {Jan Paul} and Patrick Mehlen and Pascal Meier and Sonia Melino and Miao, {Edward A.} and Molkentin, {Jeffery D.} and Moll, {Ute M.} and Cristina Mu{\~n}oz-Pinedo and Shigekazu Nagata and Gabriel Nu{\~n}ez and Andrew Oberst and Moshe Oren and Michael Overholtzer and Michele Pagano and Theocharis Panaretakis and Manolis Pasparakis and Penninger, {Josef M.} and Pereira, {David M.} and Shazib Pervaiz and Peter, {Marcus E.} and Mauro Piacentini and Paolo Pinton and Prehn, {Jochen H.M.} and Hamsa Puthalakath and Rabinovich, {Gabriel A.} and Markus Rehm and Rosario Rizzuto and Rodrigues, {Cecilia M.P.} and Rubinsztein, {David C.} and Thomas Rudel and Ryan, {Kevin M.} and Emre Sayan and Luca Scorrano and Feng Shao and Yufang Shi and John Silke and Simon, {Hans Uwe} and Antonella Sistigu and Stockwell, {Brent R.} and Andreas Strasser and Gyorgy Szabadkai and Tait, {Stephen W.G.} and Daolin Tang and Nektarios Tavernarakis and Andrew Thorburn and Yoshihide Tsujimoto and Boris Turk and {Vanden Berghe}, Tom and Peter Vandenabeele and {Vander Heiden}, {Matthew G.} and Andreas Villunger and Virgin, {Herbert W.} and Vousden, {Karen H.} and Domagoj Vucic and Wagner, {Erwin F.} and Henning Walczak and David Wallach and Ying Wang and Wells, {James A.} and Will Wood and Junying Yuan and Zahra Zakeri and Boris Zhivotovsky and Laurence Zitvogel and Gerry Melino and Guido Kroemer",

note = "Funding Information: Acknowledgements We are indebted with Dr. Avi Ashkenazi (Gen-entech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF_GR-2011-02351355), Ministero Italiano dell{\textquoteright}Is-truzione, dell{\textquoteright}Universit{\`a} e della Ricerca (MIUR, Programma per i Giovani Ricercatori “Rita Levi Montalcini” 2010). G.K. is supported by the French Ligue contre le Cancer ({\'e}quipe labellis{\'e}e); Agence National de la Recherche (ANR)—Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Canc{\'e}rop{\^o}le Ile-de-France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche M{\'e}dicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Funding Information: We are indebted with Dr. Avi Ashkenazi (Genentech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF-GR-2011-02351355), Ministero Italiano dell'Istruzione, dell'Universit? e della Ricerca (MIUR, Programma per i Giovani Ricercatori {"}Rita Levi Montalcini{"} 2010). G.K. is supported by the French Ligue contre le Cancer (?quipe labellis?e); Agence National de la Recherche (ANR)-Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Canc?rop?le Ilede- France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche M?dicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Publisher Copyright: {\textcopyright} 2018 ADMC Associazione Differenziamento e Morte Cellulare.",

year = "2018",

month = mar,

day = "1",

doi = "10.1038/s41418-017-0012-4",

language = "English (US)",

volume = "25",

pages = "486--541",

journal = "Cell Death and Differentiation",

issn = "1350-9047",

publisher = "Nature Publishing Group",

number = "3",

}

Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P, Alnemri, ES, Altucci, L, Amelio, I, Andrews, DW, Annicchiarico-Petruzzelli, M, Antonov, AV, Arama, E, Baehrecke, EH, Barlev, NA, Bazan, NG, Bernassola, F, Bertrand, MJM, Bianchi, K, Blagosklonny, MV, Blomgren, K, Borner, C, Boya, P, Brenner, C, Campanella, M, Candi, E, Carmona-Gutierrez, D, Cecconi, F, Chan, FKM, Chandel, NS, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Cohen, GM, Conrad, M, Cubillos-Ruiz, JR, Czabotar, PE, D'Angiolella, V, Dawson, TM, Dawson, VL, De Laurenzi, V, De Maria, R, Debatin, KM, Deberardinis, RJ, Deshmukh, M, Di Daniele, N, Di Virgilio, F, Dixit, VM, Dixon, SJ, Duckett, CS, Dynlacht, BD, El-Deiry, WS, Elrod, JW, Fimia, GM, Fulda, S, García-Sáez, AJ, Garg, AD, Garrido, C, Gavathiotis, E, Golstein, P, Gottlieb, E, Green, DR, Greene, LA, Gronemeyer, H, Gross, A, Hajnoczky, G, Hardwick, JM, Harris, IS, Hengartner, MO, Hetz, C, Ichijo, H, Jäättelä, M, Joseph, B, Jost, PJ, Juin, PP, Kaiser, WJ, Karin, M, Kaufmann, T, Kepp, O, Kimchi, A, Kitsis, RN, Klionsky, DJ, Knight, RA, Kumar, S, Lee, SW, Lemasters, JJ, Levine, B, Linkermann, A, Lipton, SA, Lockshin, RA, López-Otín, C, Lowe, SW, Luedde, T, Lugli, E, MacFarlane, M, Madeo, F, Malewicz, M, Malorni, W, Manic, G, Marine, JC, Martin, SJ, Martinou, JC, Medema, JP, Mehlen, P, Meier, P, Melino, S, Miao, EA, Molkentin, JD, Moll, UM, Muñoz-Pinedo, C, Nagata, S, Nuñez, G, Oberst, A, Oren, M, Overholtzer, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, JM, Pereira, DM, Pervaiz, S, Peter, ME, Piacentini, M, Pinton, P, Prehn, JHM, Puthalakath, H, Rabinovich, GA, Rehm, M, Rizzuto, R, Rodrigues, CMP, Rubinsztein, DC, Rudel, T, Ryan, KM, Sayan, E, Scorrano, L, Shao, F, Shi, Y, Silke, J, Simon, HU, Sistigu, A, Stockwell, BR, Strasser, A, Szabadkai, G, Tait, SWG, Tang, D, Tavernarakis, N, Thorburn, A, Tsujimoto, Y, Turk, B, Vanden Berghe, T, Vandenabeele, P, Vander Heiden, MG, Villunger, A, Virgin, HW, Vousden, KH, Vucic, D, Wagner, EF, Walczak, H, Wallach, D, Wang, Y, Wells, JA, Wood, W, Yuan, J, Zakeri, Z, Zhivotovsky, B, Zitvogel, L, Melino, G & Kroemer, G 2018, 'Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018', Cell Death and Differentiation, vol. 25, no. 3, pp. 486-541. https://doi.org/10.1038/s41418-017-0012-4

TY - JOUR

T1 - Molecular mechanisms of cell death

T2 - Recommendations of the Nomenclature Committee on Cell Death 2018

AU - Galluzzi, Lorenzo

AU - Vitale, Ilio

AU - Aaronson, Stuart A.

AU - Abrams, John M.

AU - Adam, Dieter

AU - Agostinis, Patrizia

AU - Alnemri, Emad S.

AU - Altucci, Lucia

AU - Amelio, Ivano

AU - Andrews, David W.

AU - Annicchiarico-Petruzzelli, Margherita

AU - Antonov, Alexey V.

AU - Arama, Eli

AU - Baehrecke, Eric H.

AU - Barlev, Nickolai A.

AU - Bazan, Nicolas G.

AU - Bernassola, Francesca

AU - Bertrand, Mathieu J.M.

AU - Bianchi, Katiuscia

AU - Blagosklonny, Mikhail V.

AU - Blomgren, Klas

AU - Borner, Christoph

AU - Boya, Patricia

AU - Brenner, Catherine

AU - Campanella, Michelangelo

AU - Candi, Eleonora

AU - Carmona-Gutierrez, Didac

AU - Cecconi, Francesco

AU - Chan, Francis K.M.

AU - Chandel, Navdeep S.

AU - Cheng, Emily H.

AU - Chipuk, Jerry E.

AU - Cidlowski, John A.

AU - Ciechanover, Aaron

AU - Cohen, Gerald M.

AU - Conrad, Marcus

AU - Cubillos-Ruiz, Juan R.

AU - Czabotar, Peter E.

AU - D'Angiolella, Vincenzo

AU - Dawson, Ted M.

AU - Dawson, Valina L.

AU - De Laurenzi, Vincenzo

AU - De Maria, Ruggero

AU - Debatin, Klaus Michael

AU - Deberardinis, Ralph J.

AU - Deshmukh, Mohanish

AU - Di Daniele, Nicola

AU - Di Virgilio, Francesco

AU - Dixit, Vishva M.

AU - Dixon, Scott J.

AU - Duckett, Colin S.

AU - Dynlacht, Brian D.

AU - El-Deiry, Wafik S.

AU - Elrod, John W.

AU - Fimia, Gian Maria

AU - Fulda, Simone

AU - García-Sáez, Ana J.

AU - Garg, Abhishek D.

AU - Garrido, Carmen

AU - Gavathiotis, Evripidis

AU - Golstein, Pierre

AU - Gottlieb, Eyal

AU - Green, Douglas R.

AU - Greene, Lloyd A.

AU - Gronemeyer, Hinrich

AU - Gross, Atan

AU - Hajnoczky, Gyorgy

AU - Hardwick, J. Marie

AU - Harris, Isaac S.

AU - Hengartner, Michael O.

AU - Hetz, Claudio

AU - Ichijo, Hidenori

AU - Jäättelä, Marja

AU - Joseph, Bertrand

AU - Jost, Philipp J.

AU - Juin, Philippe P.

AU - Kaiser, William J.

AU - Karin, Michael

AU - Kaufmann, Thomas

AU - Kepp, Oliver

AU - Kimchi, Adi

AU - Kitsis, Richard N.

AU - Klionsky, Daniel J.

AU - Knight, Richard A.

AU - Kumar, Sharad

AU - Lee, Sam W.

AU - Lemasters, John J.

AU - Levine, Beth

AU - Linkermann, Andreas

AU - Lipton, Stuart A.

AU - Lockshin, Richard A.

AU - López-Otín, Carlos

AU - Lowe, Scott W.

AU - Luedde, Tom

AU - Lugli, Enrico

AU - MacFarlane, Marion

AU - Madeo, Frank

AU - Malewicz, Michal

AU - Malorni, Walter

AU - Manic, Gwenola

AU - Marine, Jean Christophe

AU - Martin, Seamus J.

AU - Martinou, Jean Claude

AU - Medema, Jan Paul

AU - Mehlen, Patrick

AU - Meier, Pascal

AU - Melino, Sonia

AU - Miao, Edward A.

AU - Molkentin, Jeffery D.

AU - Moll, Ute M.

AU - Muñoz-Pinedo, Cristina

AU - Nagata, Shigekazu

AU - Nuñez, Gabriel

AU - Oberst, Andrew

AU - Oren, Moshe

AU - Overholtzer, Michael

AU - Pagano, Michele

AU - Panaretakis, Theocharis

AU - Pasparakis, Manolis

AU - Penninger, Josef M.

AU - Pereira, David M.

AU - Pervaiz, Shazib

AU - Peter, Marcus E.

AU - Piacentini, Mauro

AU - Pinton, Paolo

AU - Prehn, Jochen H.M.

AU - Puthalakath, Hamsa

AU - Rabinovich, Gabriel A.

AU - Rehm, Markus

AU - Rizzuto, Rosario

AU - Rodrigues, Cecilia M.P.

AU - Rubinsztein, David C.

AU - Rudel, Thomas

AU - Ryan, Kevin M.

AU - Sayan, Emre

AU - Scorrano, Luca

AU - Shao, Feng

AU - Shi, Yufang

AU - Silke, John

AU - Simon, Hans Uwe

AU - Sistigu, Antonella

AU - Stockwell, Brent R.

AU - Strasser, Andreas

AU - Szabadkai, Gyorgy

AU - Tait, Stephen W.G.

AU - Tang, Daolin

AU - Tavernarakis, Nektarios

AU - Thorburn, Andrew

AU - Tsujimoto, Yoshihide

AU - Turk, Boris

AU - Vanden Berghe, Tom

AU - Vandenabeele, Peter

AU - Vander Heiden, Matthew G.

AU - Villunger, Andreas

AU - Virgin, Herbert W.

AU - Vousden, Karen H.

AU - Vucic, Domagoj

AU - Wagner, Erwin F.

AU - Walczak, Henning

AU - Wallach, David

AU - Wang, Ying

AU - Wells, James A.

AU - Wood, Will

AU - Yuan, Junying

AU - Zakeri, Zahra

AU - Zhivotovsky, Boris

AU - Zitvogel, Laurence

AU - Melino, Gerry

AU - Kroemer, Guido

N1 - Funding Information: Acknowledgements We are indebted with Dr. Avi Ashkenazi (Gen-entech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF_GR-2011-02351355), Ministero Italiano dell’Is-truzione, dell’Università e della Ricerca (MIUR, Programma per i Giovani Ricercatori “Rita Levi Montalcini” 2010). G.K. is supported by the French Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR)—Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche Médicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Funding Information: We are indebted with Dr. Avi Ashkenazi (Genentech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF-GR-2011-02351355), Ministero Italiano dell'Istruzione, dell'Universit? e della Ricerca (MIUR, Programma per i Giovani Ricercatori "Rita Levi Montalcini" 2010). G.K. is supported by the French Ligue contre le Cancer (?quipe labellis?e); Agence National de la Recherche (ANR)-Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Canc?rop?le Ilede- France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche M?dicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Publisher Copyright: © 2018 ADMC Associazione Differenziamento e Morte Cellulare.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

AB - Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

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U2 - 10.1038/s41418-017-0012-4

DO - 10.1038/s41418-017-0012-4

M3 - Review article

C2 - 29362479

AN - SCOPUS:85036533976

SN - 1350-9047

VL - 25

SP - 486

EP - 541

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 3

ER -

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

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