Molecular targeting of drug delivery systems to cancer

T. Minko, S. S. Dharap, R. I. Pakunlu, Y. Wang

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

This review presents molecular targeting approaches in anticancer drug delivery systems (DDS) and identifies new developments in these systems. Targeting approaches include passive targeting (enhanced permeability and retention effect), targeting specific tumor conditions, topical delivery and active targeting, namely, targeting organs, cells, intracellular organelles and molecules, sandwich targeting, promoter targeting, indirect targeting and targeting by external stimuli. A novel advanced proapoptotic anticancer DDS that utilizes several molecular targets will be considered. Experimental data suggest that this DDS can simultaneously: (1) induce cell death; (2) prevent adverse effects on healthy tissues; (3) suppress and prevent multidrug resistance; and (4) inhibit cellular antiapoptotic defense.

Original languageEnglish (US)
Pages (from-to)389-406
Number of pages18
JournalCurrent Drug Targets
Volume5
Issue number4
DOIs
StatePublished - May 2004

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Keywords

  • Apoptosis
  • Cancer
  • Drug delivery system
  • EPR effect
  • Molecular targeting
  • Prodrug

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