Monoclonal antibodies as probes of domain structure of the spectrin α subunit

P. D. Yurchenco, D. W. Speicher, J. S. Morrow, W. J. Knowles, V. T. Marchesi

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


A library of nine monocloncal antibodies which bind to the α subunit of human erythrocyte spectrin has been established. The specificity of these antibodies confirms the alignment and uniqueness of each of the five previously identified peptide domains in this subunit and establishes the identity of additional smaller proteolytic peptide fragments. This immunochemical approach is complementary to the identification of peptide relationships by two-dimensional chymotryptic peptide mapping, and the results of both methods are in complete agreement.

Original languageEnglish (US)
Pages (from-to)9102-9107
Number of pages6
JournalJournal of Biological Chemistry
Issue number15
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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