Monotone and near-monotone biochemical networks

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140 Scopus citations


Monotone subsystems have appealing properties as components of larger networks, since they exhibit robust dynamical stability and predictability of responses to perturbations. This suggests that natural biological systems may have evolved to be, if not monotone, at least close to monotone in the sense of being decomposable into a "small" number of monotone components, In addition, recent research has shown that much insight can be attained from decomposing networks into monotone subsystems and the analysis of the resulting interconnections using tools from control theory. This paper provides an expository introduction to monotone systems and their interconnections, describing the basic concepts and some of the main mathematical results in a largely informal fashion.

Original languageEnglish (US)
Pages (from-to)59-87
Number of pages29
JournalSystems and Synthetic Biology
Issue number2
StatePublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Molecular Biology


  • Biochemical networks
  • Dynamical systems
  • Monotone systems


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