Mouse brain organization revealed through direct genome-scale TF expression analysis

Paul A. Gray, Hui Fu, Ping Luo, Qing Zhao, Jing Yu, Annette Ferrari, Toyoaki Tenzen, Dong In Yuk, Eric F. Tsung, Zhaohui Cai, John A. Alberta, Le Ping Cheng, Yang Liu, Jan M. Stenman, M. Todd Valerius, Nathan Billings, Haesun A. Kim, Michael E. Greenberg, Andrew P. McMahon, David H. RowitchCharles D. Stiles, Qiufu Ma

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.

Original languageEnglish (US)
Pages (from-to)2255-2257
Number of pages3
JournalScience
Volume306
Issue number5705
DOIs
StatePublished - Dec 24 2004

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Statistical Factor Analysis
Transcription Factors
Genome
Brain
Atlases
Neuroglia
Genes
In Situ Hybridization
Databases
Neurons
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • General

Cite this

Gray, P. A., Fu, H., Luo, P., Zhao, Q., Yu, J., Ferrari, A., ... Ma, Q. (2004). Mouse brain organization revealed through direct genome-scale TF expression analysis. Science, 306(5705), 2255-2257. https://doi.org/10.1126/science.1104935
Gray, Paul A. ; Fu, Hui ; Luo, Ping ; Zhao, Qing ; Yu, Jing ; Ferrari, Annette ; Tenzen, Toyoaki ; Yuk, Dong In ; Tsung, Eric F. ; Cai, Zhaohui ; Alberta, John A. ; Cheng, Le Ping ; Liu, Yang ; Stenman, Jan M. ; Valerius, M. Todd ; Billings, Nathan ; Kim, Haesun A. ; Greenberg, Michael E. ; McMahon, Andrew P. ; Rowitch, David H. ; Stiles, Charles D. ; Ma, Qiufu. / Mouse brain organization revealed through direct genome-scale TF expression analysis. In: Science. 2004 ; Vol. 306, No. 5705. pp. 2255-2257.
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Gray, PA, Fu, H, Luo, P, Zhao, Q, Yu, J, Ferrari, A, Tenzen, T, Yuk, DI, Tsung, EF, Cai, Z, Alberta, JA, Cheng, LP, Liu, Y, Stenman, JM, Valerius, MT, Billings, N, Kim, HA, Greenberg, ME, McMahon, AP, Rowitch, DH, Stiles, CD & Ma, Q 2004, 'Mouse brain organization revealed through direct genome-scale TF expression analysis', Science, vol. 306, no. 5705, pp. 2255-2257. https://doi.org/10.1126/science.1104935

Mouse brain organization revealed through direct genome-scale TF expression analysis. / Gray, Paul A.; Fu, Hui; Luo, Ping; Zhao, Qing; Yu, Jing; Ferrari, Annette; Tenzen, Toyoaki; Yuk, Dong In; Tsung, Eric F.; Cai, Zhaohui; Alberta, John A.; Cheng, Le Ping; Liu, Yang; Stenman, Jan M.; Valerius, M. Todd; Billings, Nathan; Kim, Haesun A.; Greenberg, Michael E.; McMahon, Andrew P.; Rowitch, David H.; Stiles, Charles D.; Ma, Qiufu.

In: Science, Vol. 306, No. 5705, 24.12.2004, p. 2255-2257.

Research output: Contribution to journalArticle

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AU - Tenzen, Toyoaki

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AU - Tsung, Eric F.

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AU - Alberta, John A.

AU - Cheng, Le Ping

AU - Liu, Yang

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AU - Valerius, M. Todd

AU - Billings, Nathan

AU - Kim, Haesun A.

AU - Greenberg, Michael E.

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AU - Stiles, Charles D.

AU - Ma, Qiufu

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Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A et al. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24;306(5705):2255-2257. https://doi.org/10.1126/science.1104935