MRNA 3′ end processing factors: A phylogenetic comparison

Sarah K. Darmon, Carol S. Lutz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail. This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation. Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors. Here, we comprehensively compare the protein machinery responsible for polyadenylation of mRNAs across many evolutionary divergent species, and we have found these protein factors to be remarkably conserved in nature. These data suggest that polyadenylation of mRNAs is an ancient process.

Original languageEnglish (US)
Article number876893
JournalComparative and Functional Genomics
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Genetics


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