M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii

Kalyana Sundaram, Jaya Murugaian, Mark Watson, Hreday Sapru

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Bilateral microinjections (0.2-2 nmol/site) of a potent M2 muscarinic receptor agonist, cis-methyldioxolane (CD), but not those of a relatively selective M1 receptor agonist (McN-A343; 3 nmol/site), into the intermediate portion of nucleus tractus solitarii (NTS) of pentobarbital-anesthetized rats elicited a decrease in blood pressure (23-52 mm Hg) and heart rate (16-50 bpm). Previous microinjections of a selective competitive M2 receptor antagonist (AFDX-116; 0.8 nmol/site), but not those of a potent selective M1 receptor antagonist (pirenzepine; 2 nmol/site), into the NTS blocked the effects of CD. These results indicate that the muscarinic receptors in the intermediate portion of NTS are of M2 type.

Original languageEnglish (US)
Pages (from-to)358-362
Number of pages5
JournalBrain research
Volume477
Issue number1-2
DOIs
StatePublished - Jan 16 1989

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • AFDX-116
  • Blood pressure
  • Heart rate
  • M muscarinic receptor
  • M muscarinic receptor
  • McN-A343
  • Physostigmine
  • Pirenzepine
  • Wistar rat
  • cis-Methyldioxolane

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