mTOR binds to the promoters of RNA polymerase I- And III-transcribed genes

Chi Kwan Tsang, Hui Liu, X. F.Steven Zheng

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Target of rapamycin (TOR) is a conserved regulator of gene expression from yeast to humans. In budding yeast, TOR is associated with ribosomal DNA (rDNA) promoter, which is critical for ribosome biogenesis and transfer RNA (tRNA) synthesis. Whether mTOR behaves similarly in mammalian cells is unknown. Here, we report that mTOR is detected at several different promoters in human and murine cells, including that of rDNA and tRNA genes. the association of mTOR with these promoters is regulated by growth signals and sensitive to rapamycin. Together, our observations suggest that mTOR is closely involved in gene regulation at the promoters, which is a conserved mechanism to control RNA polymerase I- and III-dependent genes that are critical for protein synthesis and cell growth.

Original languageEnglish (US)
Pages (from-to)953-957
Number of pages5
JournalCell Cycle
Issue number5
StatePublished - Mar 1 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


  • Pol I
  • Pol III
  • mTOR
  • rDNA
  • tRNA


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