Multi-azole resistance in Aspergillus fumigatus

Susan J. Howard, Ian Webster, Caroline B. Moore, Rebecca E. Gardiner, Steven Park, David S. Perlin, David W. Denning

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14α-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.

Original languageEnglish (US)
Pages (from-to)450-453
Number of pages4
JournalInternational journal of antimicrobial agents
Volume28
Issue number5
DOIs
StatePublished - Nov 1 2006

Fingerprint

Azoles
Aspergillus fumigatus
Itraconazole
caspofungin
Aspergillosis
Aspergillus
Mutation
Genes
Voriconazole
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Keywords

  • Aspergillosis
  • Aspergillus
  • Azole
  • Itraconazole
  • Resistance
  • cyp51A

Cite this

Howard, S. J., Webster, I., Moore, C. B., Gardiner, R. E., Park, S., Perlin, D. S., & Denning, D. W. (2006). Multi-azole resistance in Aspergillus fumigatus. International journal of antimicrobial agents, 28(5), 450-453. https://doi.org/10.1016/j.ijantimicag.2006.08.017
Howard, Susan J. ; Webster, Ian ; Moore, Caroline B. ; Gardiner, Rebecca E. ; Park, Steven ; Perlin, David S. ; Denning, David W. / Multi-azole resistance in Aspergillus fumigatus. In: International journal of antimicrobial agents. 2006 ; Vol. 28, No. 5. pp. 450-453.
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Howard, SJ, Webster, I, Moore, CB, Gardiner, RE, Park, S, Perlin, DS & Denning, DW 2006, 'Multi-azole resistance in Aspergillus fumigatus', International journal of antimicrobial agents, vol. 28, no. 5, pp. 450-453. https://doi.org/10.1016/j.ijantimicag.2006.08.017

Multi-azole resistance in Aspergillus fumigatus. / Howard, Susan J.; Webster, Ian; Moore, Caroline B.; Gardiner, Rebecca E.; Park, Steven; Perlin, David S.; Denning, David W.

In: International journal of antimicrobial agents, Vol. 28, No. 5, 01.11.2006, p. 450-453.

Research output: Contribution to journalArticle

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T1 - Multi-azole resistance in Aspergillus fumigatus

AU - Howard, Susan J.

AU - Webster, Ian

AU - Moore, Caroline B.

AU - Gardiner, Rebecca E.

AU - Park, Steven

AU - Perlin, David S.

AU - Denning, David W.

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AB - Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14α-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.

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KW - Aspergillus

KW - Azole

KW - Itraconazole

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