Multi-azole resistance in Aspergillus fumigatus

Susan J. Howard, Ian Webster, Caroline B. Moore, Rebecca E. Gardiner, Steven Park, David S. Perlin, David W. Denning

Research output: Contribution to journalArticle

147 Scopus citations

Abstract

Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14α-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.

Original languageEnglish (US)
Pages (from-to)450-453
Number of pages4
JournalInternational journal of antimicrobial agents
Volume28
Issue number5
DOIs
StatePublished - Nov 1 2006

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Keywords

  • Aspergillosis
  • Aspergillus
  • Azole
  • Itraconazole
  • Resistance
  • cyp51A

Cite this

Howard, S. J., Webster, I., Moore, C. B., Gardiner, R. E., Park, S., Perlin, D. S., & Denning, D. W. (2006). Multi-azole resistance in Aspergillus fumigatus. International journal of antimicrobial agents, 28(5), 450-453. https://doi.org/10.1016/j.ijantimicag.2006.08.017