Abstract
The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 174-179 |
| Number of pages | 6 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1378 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1 2016 |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Keywords
- bifunctionals
- chloroethylethylsulfide
- inflammation
- phorbol ester
- skin
- sulfur mustard
- vesicants
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Cite this
Lacey, C. J., Wohlman, I., Guillon, C., Saxena, J., Fianu-Velgus, C., Aponte, E., Young, S. C., Heck, D. E., Joseph, L. B., Laskin, J. D., & Heindel, N. D. (2016). Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Annals of the New York Academy of Sciences, 1378(1), 174-179. https://doi.org/10.1111/nyas.13177