Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Carl J. Lacey, Irene Wohlman, Christophe Guillon, Jaya Saxena, Cynthia Fianu-Velgus, Erik Aponte, Sherri C. Young, Diane E. Heck, Laurie B. Joseph, Jeffrey D. Laskin, Ned D. Heindel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1378
Issue number1
DOIs
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Keywords

  • bifunctionals
  • chloroethylethylsulfide
  • inflammation
  • phorbol ester
  • skin
  • sulfur mustard
  • vesicants

Fingerprint Dive into the research topics of 'Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury'. Together they form a unique fingerprint.

  • Cite this

    Lacey, C. J., Wohlman, I., Guillon, C., Saxena, J., Fianu-Velgus, C., Aponte, E., Young, S. C., Heck, D. E., Joseph, L. B., Laskin, J. D., & Heindel, N. D. (2016). Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Annals of the New York Academy of Sciences, 1378(1), 174-179. https://doi.org/10.1111/nyas.13177