Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Carl J. Lacey; Irene Wohlman; Christophe Guillon; Jaya Saxena; Cynthia Fianu-Velgus; Erik Aponte; Sherri C. Young; Diane E. Heck; Laurie B. Joseph; Jeffrey D. Laskin; Ned D. Heindel

doi:10.1111/nyas.13177

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Carl J. Lacey, Irene Wohlman, Christophe Guillon, Jaya Saxena, Cynthia Fianu-Velgus, Erik Aponte, Sherri C. Young, Diane E. Heck, Laurie B. Joseph, Jeffrey D. Laskin, Ned D. Heindel

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.

Original language	English (US)
Pages (from-to)	174-179
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1378
Issue number	1
DOIs	https://doi.org/10.1111/nyas.13177
State	Published - Aug 1 2016

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Keywords

bifunctionals
chloroethylethylsulfide
inflammation
phorbol ester
skin
sulfur mustard
vesicants

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10.1111/nyas.13177

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Lacey, C. J., Wohlman, I., Guillon, C., Saxena, J., Fianu-Velgus, C., Aponte, E., Young, S. C., Heck, D. E., Joseph, L. B., Laskin, J. D., & Heindel, N. D. (2016). Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Annals of the New York Academy of Sciences, 1378(1), 174-179. https://doi.org/10.1111/nyas.13177

Lacey, Carl J. ; Wohlman, Irene ; Guillon, Christophe ; Saxena, Jaya ; Fianu-Velgus, Cynthia ; Aponte, Erik ; Young, Sherri C. ; Heck, Diane E. ; Joseph, Laurie B. ; Laskin, Jeffrey D. ; Heindel, Ned D. / Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. In: Annals of the New York Academy of Sciences. 2016 ; Vol. 1378, No. 1. pp. 174-179.

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title = "Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury",

abstract = "The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.",

keywords = "bifunctionals, chloroethylethylsulfide, inflammation, phorbol ester, skin, sulfur mustard, vesicants",

author = "Lacey, {Carl J.} and Irene Wohlman and Christophe Guillon and Jaya Saxena and Cynthia Fianu-Velgus and Erik Aponte and Young, {Sherri C.} and Heck, {Diane E.} and Joseph, {Laurie B.} and Laskin, {Jeffrey D.} and Heindel, {Ned D.}",

note = "Funding Information: This work is supported by the National Institutes of Health and National Institute of Arthritis and Musculoskeletal and Skin Diseases (Grant Number U54-AR055073).",

year = "2016",

month = aug,

day = "1",

doi = "10.1111/nyas.13177",

language = "English (US)",

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Lacey, CJ, Wohlman, I, Guillon, C, Saxena, J, Fianu-Velgus, C, Aponte, E, Young, SC, Heck, DE, Joseph, LB, Laskin, JD & Heindel, ND 2016, 'Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury', Annals of the New York Academy of Sciences, vol. 1378, no. 1, pp. 174-179. https://doi.org/10.1111/nyas.13177

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. / Lacey, Carl J.; Wohlman, Irene; Guillon, Christophe; Saxena, Jaya; Fianu-Velgus, Cynthia; Aponte, Erik; Young, Sherri C.; Heck, Diane E.; Joseph, Laurie B.; Laskin, Jeffrey D.; Heindel, Ned D.

In: Annals of the New York Academy of Sciences, Vol. 1378, No. 1, 01.08.2016, p. 174-179.

Research output: Contribution to journal › Article › peer-review

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AU - Lacey, Carl J.

AU - Wohlman, Irene

AU - Guillon, Christophe

AU - Saxena, Jaya

AU - Fianu-Velgus, Cynthia

AU - Aponte, Erik

AU - Young, Sherri C.

AU - Heck, Diane E.

AU - Joseph, Laurie B.

AU - Laskin, Jeffrey D.

AU - Heindel, Ned D.

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