Multifunctional nanomedicine platform for cancer specific delivery of sirna by superparamagnetic iron oxide nanoparticles-dendrimer complexes

Oleh Taratula, Olga Garbuzenko, Ronak Savla, Y. Andrew Wang, Huixin He, Tamara Minko

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

The ability of Superparamagnetic Iron Oxide (SPIO) nanoparticles and Poly(Propyleneimine) generation 5 dendrimers (PPI G5) to cooperatively provoke siRNA complexation was investigated in order to develop a targeted, multifunctional siRNA delivery system for cancer therapy. Poly(ethylene glycol) (PEG) coating and cancer specific targeting moiety (LHRH peptide) have been incorporated into SPIO-PPI G5-siRNA complexes to enhance serum stability and selective internalization by cancer cells. Such a modification of siRNA nanoparticles enhanced its internalization into cancer cells and increased the efficiency of targeted gene suppression in vitro. Moreover, the developed siRNA delivery system was capable of sufficiently enhancing in vivo antitumor activity of an anticancer drug (Cisplatin). The proposed approach demonstrates potential for the creation of targeted multifunctional nanomedicine platforms with the ability to deliver therapeutic siRNA specifically to cancer cells in order to prevent severe adverse side effects on healthy tissues and in situ monitoring of the therapeutic outcome using clinically relevant imaging techniques.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalCurrent Drug Delivery
Volume8
Issue number1
DOIs
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Cisplatin
  • Imaging
  • LHRH peptide
  • PPI dendrimer
  • SPIO nanoparticles
  • SiRNA
  • Tumor targeting

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