Multiphase blends from poly(L-lactide) and poly(methyl mathacrylate)

Kim Phuong Le, Richard Lehman, Jessica Remmert, Kenneth Vanness, Paula Marie L. Ward, James D. Idol

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Melt processing of poly(L-lactide) (PLLA) and poly(methyl methacrylate) (PMMA) was conducted over a targeted range of compositions with PLLAs of 118 and 316 kDa in molecular mass to identify morphologies and the phase relationships in these blends. These blends are of interest for use in biomaterials and the morphologies are critical for tissue-engineering studies where biodegradability, pore connectivity and surface texture control tissue viability and adhesion. Simple extrusion of the two polymers produced multiphase blends with an average domain size near 25 μm. Scanning electron microscopy and dynamic mechanical analysis demonstrated that these blends are immiscible, at least in a metastable sense, and regions of co-continuous structures were identified. Such co-continuous, which occurred generally in accordance with rheology prediction models, exhibit a fine interconnected structure that appears effective for fabricating certain biomaterials. A broad and unexpected transition appears in these blends, as measured by modulated differential scanning calorimetry between 70 and 100°C, which may be the glass transition temperature of an alloy phase. The magnitude of this transition is greatest in the fine-structured co-continuous composition region of blends, suggesting the presence of a complex or other derivative of the two primary phases.

Original languageEnglish (US)
Pages (from-to)121-137
Number of pages17
JournalJournal of Biomaterials Science, Polymer Edition
Issue number1
StatePublished - Jan 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


  • Bioresorbable
  • Extrusion
  • Immiscibility
  • Polymer blend
  • Scaffold
  • Tissue engineering


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