Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats

J. H. Zhang, L. Huang, M. P. Mehta, J. H. Eichhorn, A. Nanda

Research output: Contribution to journalArticle

4 Scopus citations


Hyperbaric oxygenation (HBO) therapy has been reported to improve neurological recovery following spinal cord injury (SCI). In the present study, we examined whether multiple HBO expands the therapeutic window for acute SCI. Single HBO (2.8 ATA, 1 hour) treatment was used at 30 minutes, 3 hours, and 6 hours following SCI, and serial HBO treatment (once daily for 1 week) at 6 hours and 24 hours post-injury. Mild SCI was induced by adjusting the height for a weight drop insult (10 g) to 6.25 mm above the exposed spinal cord. The group of animals receiving a single HBO intervention beginning at 30 minutes and 3 hours, or serial HBO treatment starting at 6 hours following the injury had a significantly better neurological recovery than animals with SCI only. The results of this study demonstrate that multiple HBO expands the therapeutic window for acute SCI to 6 hours after injury, further that serial HBO administration is superior to single HBO therapy.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalActa Neurochirurgica, Supplementum
Issue number86
StatePublished - Jan 1 2003
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


  • Behavior
  • Hyperbaric oxygen
  • Spinal cord injury
  • Therapy

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