TY - GEN
T1 - Multiplexed molecular assays using nanoelectronically barcoded beads
AU - Xie, Pengfei
AU - Cao, Xinnan
AU - Javanmard, Mehdi
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/2/26
Y1 - 2016/2/26
N2 - Barcoding of microparticles has been widely used for performing multiplex genomic and proteomic assays. The most common methods of barcoding are optical and plasmonic which requires large and bulky instrumentation for performing the readout, which is unsuitable for portable devices requiring small instrumentation footprint. We introduce the concept of electronically barcoded micron-sized beads, which to the best of our knowledge, is the first time an impedance based barcoding technique for beads has been used with the potential of achieving high barcode density. Nanoelectronic barcoding works by fabricating tunable nano-capacitors on the micro-particle surface, effectively modulating the frequency dependent dielectric properties of the particles allowing one bead barcode to be distinguished from another. Multi-frequency lock-in measurements of the real to imaginary impedance ratio allows for bead differentiation.
AB - Barcoding of microparticles has been widely used for performing multiplex genomic and proteomic assays. The most common methods of barcoding are optical and plasmonic which requires large and bulky instrumentation for performing the readout, which is unsuitable for portable devices requiring small instrumentation footprint. We introduce the concept of electronically barcoded micron-sized beads, which to the best of our knowledge, is the first time an impedance based barcoding technique for beads has been used with the potential of achieving high barcode density. Nanoelectronic barcoding works by fabricating tunable nano-capacitors on the micro-particle surface, effectively modulating the frequency dependent dielectric properties of the particles allowing one bead barcode to be distinguished from another. Multi-frequency lock-in measurements of the real to imaginary impedance ratio allows for bead differentiation.
UR - http://www.scopus.com/inward/record.url?scp=84970965943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84970965943&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2016.7421624
DO - 10.1109/MEMSYS.2016.7421624
M3 - Conference contribution
AN - SCOPUS:84970965943
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 317
EP - 320
BT - MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016
Y2 - 24 January 2016 through 28 January 2016
ER -