Multivariate analysis of HLA-disease associations.

P. E. Smouse, R. C. Williams

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A multivariate procedure is presented for the analysis of HLA-disease associations. This formulation explicitly accounts for the inner correlations of the HLA complex itself, both within loci (arising from the fact that multinomial allelic frequencies must sum to unity) and between loci (arising from a failure of independent assortment). The analysis yields a single test criterion for association of the HLA complex, as a whole, with the disease in question: this criterion has an approximately chi square distribution. The overall test may conveniently be partitioned into a variety of interesting and independent subtests, so a decomposition of the problem is possible. The analysis is illustrated with data derived from a study of guttate psoriasis by Williams et al. (1976, British Journal of Dermatology 95, 163-167). Extensions to related problems are indicated.

Original languageEnglish (US)
Pages (from-to)757-768
Number of pages12
Issue number3
StatePublished - Sep 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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