Muscarinic acetylcholine receptor subtype mRNAs in the human and rat vestibular periphery

Phillip A. Wackym, Caroline T. Chen, Akira Ishiyama, Robert M. Pettis, Iván A. López, Larry Hoffman

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The expression of the five muscarinic acetylcholine receptor (mAChR) subtypes (m1-m5) in the vestibular end-organs and in the primary afferent vestibular ganglia of the human and rat was studied using RT-PCR from the two tissue populations from both species. In the human, although all five mAChR subtypes were expressed in brain, only the m1, m2, and m5 mAChR subtypes were amplified from both the vestibular ganglia and the vestibular end-organs, while in the rat, all five mAChR subtypes were expressed. These data suggest that the efferent cholinergic axo-dendritic and axe-somatic synapses have a muscarinic component and that there are pharmacologic implications for patients with vestibular dysfunction.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalCell Biology International
Volume20
Issue number3
DOIs
StatePublished - Mar 1996

All Science Journal Classification (ASJC) codes

  • Cell Biology

Keywords

  • Gene expression
  • Muscarinic acetylcholine receptor
  • Neurochemistry
  • RT-PCR
  • Vestibular

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