Muscarinic cholinergic receptors flow in the sciatic nerve

James K. Wamsley, Marco A. Zarbin, Michael J. Kuhar

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Muscarinic cholinergic receptors build up on the proximal side of a ligature placed on the rat sciatic and vagus nerves. These receptors appear to be flowing down the axons of at least a portion of the nerve fibers present in sciatic and vagus nerves. Most of the anterograde flowing muscarinic binding sites are displaceable with 10-4 M carbachol indicating that many are high affinity agonist binding sites. These receptors can also be localized in the ganglionic nerve cell bodies in the dorsal root ganglia which contribute fibers to the sciatic nerve. We hypothesize that muscarinic cholinergic receptors are synthesized in the ganglion cell bodies and transported distally in sensory nerve axons in the sciatic nerve.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalBrain research
Issue number1
StatePublished - Jul 27 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • axonal transport
  • dorsal root ganglion
  • high affinity agonist site
  • muscarinic cholinergic receptor
  • sciatic nerve
  • vagus nerve


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