Mutacin II, a bactericidal lantibiotic from Streptococcus mutans

M. L. Chikindas, J. Novak, A. J.M. Driessen, W. N. Konings, K. M. Schilling, P. W. Caufield

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Mutacin II is a lantibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin 11 possesses bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (Δψ) and the transmembrane pH gradient (ΔpH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming lantibiotics (type A) or to the type B lantibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin 11 acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has nut yet been classified for lantibiotics.

Original languageEnglish (US)
Pages (from-to)2656-2660
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume39
Issue number12
DOIs
StatePublished - Jan 1 1995

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Bacteriocins
Streptococcus mutans
Adenosine Triphosphate
Proton-Motive Force
Nuts
Peptidoglycan
Phospholipases
Streptococcus
Membrane Potentials
Amino Acids
Glucose
mutacin II
Enzymes
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Chikindas, M. L., Novak, J., Driessen, A. J. M., Konings, W. N., Schilling, K. M., & Caufield, P. W. (1995). Mutacin II, a bactericidal lantibiotic from Streptococcus mutans. Antimicrobial agents and chemotherapy, 39(12), 2656-2660. https://doi.org/10.1128/AAC.39.12.2656
Chikindas, M. L. ; Novak, J. ; Driessen, A. J.M. ; Konings, W. N. ; Schilling, K. M. ; Caufield, P. W. / Mutacin II, a bactericidal lantibiotic from Streptococcus mutans. In: Antimicrobial agents and chemotherapy. 1995 ; Vol. 39, No. 12. pp. 2656-2660.
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Chikindas, ML, Novak, J, Driessen, AJM, Konings, WN, Schilling, KM & Caufield, PW 1995, 'Mutacin II, a bactericidal lantibiotic from Streptococcus mutans', Antimicrobial agents and chemotherapy, vol. 39, no. 12, pp. 2656-2660. https://doi.org/10.1128/AAC.39.12.2656

Mutacin II, a bactericidal lantibiotic from Streptococcus mutans. / Chikindas, M. L.; Novak, J.; Driessen, A. J.M.; Konings, W. N.; Schilling, K. M.; Caufield, P. W.

In: Antimicrobial agents and chemotherapy, Vol. 39, No. 12, 01.01.1995, p. 2656-2660.

Research output: Contribution to journalArticle

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