Mutagenicity of aminophenyl and nitrophenyl ethers, sulfides, and disulfides

Edmond Lavoie, Lorraine Tulley, Elizabeth Fow, Dietrich Hoffmann

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46 Scopus citations


The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4′-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4′-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, S > O > CH2CH2 {slanted equal to or greater-than} SS. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-aminophenyl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester strains TA100 and TA98.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalMutation Research/Genetic Toxicology
Issue number2
StatePublished - Jun 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Genetics


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