TY - JOUR
T1 - Mutagenicity of aminophenyl and nitrophenyl ethers, sulfides, and disulfides
AU - Lavoie, Edmond
AU - Tulley, Lorraine
AU - Fow, Elizabeth
AU - Hoffmann, Dietrich
N1 - Funding Information:
* This study was supported by National Cancer Institute Grant CA 17613.
PY - 1979/6
Y1 - 1979/6
N2 - The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4′-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4′-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, S > O > CH2CH2 {slanted equal to or greater-than} SS. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-aminophenyl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester strains TA100 and TA98.
AB - The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4′-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4′-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, S > O > CH2CH2 {slanted equal to or greater-than} SS. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-aminophenyl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester strains TA100 and TA98.
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U2 - 10.1016/0165-1218(79)90123-X
DO - 10.1016/0165-1218(79)90123-X
M3 - Article
C2 - 381912
AN - SCOPUS:0018386164
SN - 0165-1218
VL - 67
SP - 123
EP - 131
JO - Mutation Research/Genetic Toxicology
JF - Mutation Research/Genetic Toxicology
IS - 2
ER -