TY - JOUR
T1 - Mutant prevention concentration as a measure of antibiotic potency
T2 - Studies with clinical isolates of Mycobacterium tuberculosis
AU - Dong, Y.
AU - Zhao, X.
AU - Kreiswlrth, B. N.
AU - Drlica, K.
PY - 2000
Y1 - 2000
N2 - The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in having MPCs below the maximum concentration attained in serum by use of commonly recommended doses.
AB - The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in having MPCs below the maximum concentration attained in serum by use of commonly recommended doses.
UR - http://www.scopus.com/inward/record.url?scp=0033836018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033836018&partnerID=8YFLogxK
U2 - 10.1128/AAC.44.9.2581-2584.2000
DO - 10.1128/AAC.44.9.2581-2584.2000
M3 - Article
C2 - 10952625
AN - SCOPUS:0033836018
SN - 0066-4804
VL - 44
SP - 2581
EP - 2584
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
ER -