Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region

S. M. Friedman; T. Lu; K. Drlica

doi:10.1128/AAC.45.8.2378-2380.2001

Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region

S. M. Friedman, T. Lu, K. Drlica

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88 Scopus citations

Abstract

In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.

Original language	English (US)
Pages (from-to)	2378-2380
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	8
DOIs	https://doi.org/10.1128/AAC.45.8.2378-2380.2001
State	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.45.8.2378-2380.2001

Cite this

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title = "Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region",

abstract = "In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.",

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AU - Friedman, S. M.

AU - Lu, T.

AU - Drlica, K.

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N2 - In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.

AB - In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.

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ER -

Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region

Abstract

All Science Journal Classification (ASJC) codes

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