Mutational analysis of the carboxyl terminus of the Moloney murine leukemia virus integration protein

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Abstract

The integration protein (IN) is required for retrovirus DNA integration into the host DNA. The function of the C terminus of the Moloney murine leukemia virus IN protein was examined. The terminal 28 amino acids were found to be nonessential. A linker insertion at position 6025, within a 26-amino-acid insertion not found in any other retrovirus, also produced viable virus.

Original languageEnglish (US)
Pages (from-to)2141-2145
Number of pages5
JournalJournal of virology
Volume65
Issue number4
DOIs
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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