Mycobacterial extracellular vesicles and host pathogen interactions

Shamba Gupta, G. Marcela Rodriguez

Research output: Contribution to journalShort surveypeer-review

23 Scopus citations

Abstract

Mycobacteria, like other bacteria, archaea and eukaryotic cells, naturally release extracellular vesicles (EVs) to interact with their environment. EVs produced by pathogenic bacteria are involved in many activities including cell-cell communication, immunomodulation, virulence and cell survival. Although EVs released by thick cell wall microorganisms like mycobacteria were recognized only recently, studies of Mycobacterium tuberculosis EVs already point to their important roles in host pathogen interactions, opening exciting new areas of investigation. This minireview will summarize the current understanding of mycobacterial EV biology and roles in pathogenesis and will discuss their potential therapeutic applications.

Original languageEnglish (US)
Article numberfty031
JournalPathogens and disease
Volume76
Issue number4
DOIs
StatePublished - Jun 1 2018

All Science Journal Classification (ASJC) codes

  • General Medicine

Keywords

  • Immunomodulation
  • Iron
  • Membrane vesicles
  • Mycobacterium
  • Pathogenicity
  • Secretion

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