Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Yixiong Heng; Peck Gee Seah; Jie Yee Siew; Hui Chien Tay; Amit Singhal; Vanessa Mathys; Mehdi Kiass; Pablo Bifani; Véronique Dartois; Maxime Hervé

doi:10.1016/j.tube.2011.05.003

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Yixiong Heng, Peck Gee Seah, Jie Yee Siew, Hui Chien Tay, Amit Singhal, Vanessa Mathys, Mehdi Kiass, Pablo Bifani, Véronique Dartois, Maxime Hervé

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

Original language	English (US)
Pages (from-to)	339-341
Number of pages	3
Journal	Tuberculosis
Volume	91
Issue number	4
DOIs	https://doi.org/10.1016/j.tube.2011.05.003
State	Published - Jul 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

Keywords

Histopathology
Hypoxia
Pimonidazole
Rat
Tuberculosis

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10.1016/j.tube.2011.05.003

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title = "Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat",

abstract = "Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.",

keywords = "Histopathology, Hypoxia, Pimonidazole, Rat, Tuberculosis",

author = "Yixiong Heng and Seah, {Peck Gee} and Siew, {Jie Yee} and Tay, {Hui Chien} and Amit Singhal and Vanessa Mathys and Mehdi Kiass and Pablo Bifani and V{\'e}ronique Dartois and Maxime Herv{\'e}",

note = "Funding Information: We are grateful to Wong Hui Sian and Dr. Veronique Angeli (National University of Singapore, Immunology Program, Microbiology Department) for their technical assistance. We also thank Dr. Gilla Kaplan for critical review of the study. This work was funded by the Bill and Melinda Gates foundation (Grant Accelerator ID45728 ). ",

year = "2011",

month = jul,

doi = "10.1016/j.tube.2011.05.003",

language = "English (US)",

volume = "91",

pages = "339--341",

journal = "Tuberculosis",

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AU - Heng, Yixiong

AU - Seah, Peck Gee

AU - Siew, Jie Yee

AU - Tay, Hui Chien

AU - Singhal, Amit

AU - Mathys, Vanessa

AU - Kiass, Mehdi

AU - Bifani, Pablo

AU - Dartois, Véronique

AU - Hervé, Maxime

N1 - Funding Information: We are grateful to Wong Hui Sian and Dr. Veronique Angeli (National University of Singapore, Immunology Program, Microbiology Department) for their technical assistance. We also thank Dr. Gilla Kaplan for critical review of the study. This work was funded by the Bill and Melinda Gates foundation (Grant Accelerator ID45728 ).

PY - 2011/7

Y1 - 2011/7

N2 - Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

AB - Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

KW - Histopathology

KW - Hypoxia

KW - Pimonidazole

KW - Rat

KW - Tuberculosis

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VL - 91

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JO - Tuberculosis

JF - Tuberculosis

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ER -

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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