Myelination by transplanted fetal and neonatal oligodendrocytes in a dysmyelinating mutant

Emily Friedman, Gajanan Nilaver, Peter Carmel, Mark Perlow, Linda Spatz, Norman Latov

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Demyelination is a major feature of CNS injury and disease, including multiple sclerosis. To examine the potential for myelination by transplanted oligodendrocytes, initially described by Gumpel et al., we have transplanted neonatal cortex of mice with normal myelin into a dysmyelinating mutant, the shiverer mouse. We have found that oligodendrocyte precursors mature and synthesize myelin following transplantation. Immunostaining with antibodies to myelin basic protein (MBP), neurofilament protein and glial fibrillary acidic protein, demonstrates myelination both within the graft and extending out into the host, axonal sprouting from the graft which parallels the MBP-reactivity, and minimal astrocytic proliferation in response to the transplant.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalBrain research
Volume378
Issue number1
DOIs
StatePublished - Jul 16 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • CNS transplantation
  • glial fibrillary acidic protein
  • myelin
  • myelin basic protein
  • neurofilament protein
  • shiverer

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