Myeloid leukemia cutis in the setting of myelodysplastic syndrome: A crucial dermatological diagnosis

Laju M. Patel, Amin Maghari, Robert A. Schwartz, Rajendra Kapila, Aaron J. Morgan, W. Clark Lambert

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Cutaneous involvement by myeloid leukemic cells is an unusual phenomenon. Clinical manifestations vary from erythematous papules to plum-colored plaques and nodules that may become purpuric and ulcerate. The definitive diagnosis of myeloid leukemia cutis requires the analysis of biopsy specimens using immunohistochemical staining to determine the expression of selective cell surface markers. We will review myeloid leukemia when first evident in the skin, particularly in the setting of myelodysplastic syndrome. The diagnosis of leukemia cutis in patients with myelodysplastic syndrome is indicative of concomitant or impending acute leukemic transformation. The early recognition and accurate identification of leukemic skin infiltrates in myelodysplastic patients is crucial, as this finding can have significant therapeutic and prognostic implications.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalInternational journal of dermatology
Volume51
Issue number4
DOIs
StatePublished - Apr 2012

All Science Journal Classification (ASJC) codes

  • Dermatology

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