In this Microreview, we describe the recent exciting developments in the burgeoning area of amide N–C cross-coupling enabled by amide bond twist of N-acyl-glutarimides. Since the initial reports in 2015, these amides have been demonstrated to be by far the most reactive amide derivatives in the biologically-relevant manifold of N–C activation/cross-coupling, thus stimulating the development of more than 10 previously unknown catalytic modes of reactivity of the amide bond. The capacity of N-acyl-glutarimides as privileged scaffolds to expedite acyl and decarbonylative cross-couplings by amide N–C cleavage is discussed.
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry
- Decarbonylative coupling
- N–C activation
- Twisted amides