Nanomaterials for stem cell imaging in the central nervous system

Aniruddh Solanki, Shreyas Shah, Michael H. Koucky, Ki Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stem cells hold great potential for the treatment of various injuries and degenerative diseases as they possess the unique ability to self-renew and differentiate into specific cell lineages. They hold great promise for treating diseases and injuries especially within the central nervous system. For instance, the role of stem cells in regenerative medicine has been suggested for degenerative diseases such as Parkinson’s and Alzheimer’s. Not only are they promising for degenerative diseases, but also for treating spinal cord injuries and traumatic brain injuries. Such injuries significantly impair the ability of the central nervous system to communicate, leading to a host of debilitating symptoms, eventually resulting in an ultimate loss of function. The discovery and applications of stem cells offers a flicker of hope to the patients tormented by these diseases and injuries. However, before the therapeutic applications of stem cells in regenerative medicine can be fully realized, several obstacles need to be overcome. One of the biggest obstacles is tracking and mapping the location of the transplanted stem cells within the central nervous system. The development of nanotechnology in recent years and its application to stem cell biology will play a significant role in addressing these challenges. This chapter details the unique properties and current applications of nanomaterials for labeling and tracking transplanted stem cells within the central nervous system using various imaging techniques.

Original languageEnglish (US)
Title of host publicationNanomedicine and the Nervous System
PublisherCRC Press
Pages162-182
Number of pages21
ISBN (Electronic)9781466505117
ISBN (Print)9781578087280
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Engineering(all)

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