Nanomedicine for the treatment of retinal and optic nerve diseases

Marco Attilio Zarbin, Carlo Montemagno, James Francis Leary, Robert Ritch

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

The earliest impact of nanomedicine in ophthalmology is likely to involve the areas of biopharmaceuticals, implantable materials (e.g. tissue regeneration scaffolds, bioresorbable materials), implantable devices (e.g. glaucoma drainage valves), and diagnostic tools (e.g. intraocular pressure (IOP) monitors). Nanotechnology will bring about the development of regenerative medicine (i.e. replacement and improvement of cells, tissues, and organs) and artificial vision. In this chapter, we review ophthalmic applications of nanotechnology in the following areas: drug and trophic factor therapy for glaucoma, retinal degenerative, and retinal vascular disease; gene therapy for retinal degenerative disease; regenerative medicine, including optogenetics and optic nerve regeneration; and diagnostics (minimally invasive IOP monitoring). Nanotechnology will play an important role in both early-stage and late-stage intervention in the management of blinding diseases.

Original languageEnglish (US)
Pages (from-to)134-148
Number of pages15
JournalCurrent Opinion in Pharmacology
Volume13
Issue number1
DOIs
StatePublished - Feb 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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