Nanoparticle design considerations for molecular imaging of apoptosis: Diagnostic, prognostic, and therapeutic value

Ronak Savla, Tamara Minko

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

The present review analyzes various approaches for the design and synthesis of different nanoparticles for imaging and therapy. Nanoparticles for computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and optical imaging are discussed. The influence of nanoparticle size, shape, surface charge, composition, surface functionalization, active targeting and other factors on imaging and therapeutic efficacy is analyzed. Cyto- and genotoxicity of nanoparticles are also discussed. Special attention in the review is paid to the imaging of apoptotic tissues and cells in different diseases.

Original languageEnglish (US)
Pages (from-to)122-140
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume113
DOIs
StatePublished - Apr 2017

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Apoptosis
  • Computed tomography
  • Magnetic resonance
  • Nanoparticle
  • Theranostic

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