TY - JOUR
T1 - Nanoparticle design considerations for molecular imaging of apoptosis
T2 - Diagnostic, prognostic, and therapeutic value
AU - Savla, Ronak
AU - Minko, Tamara
N1 - Funding Information:
This work was supported in part by grants from the National Institutes of Health: R01 CA138533 and R01 HL118312.
Publisher Copyright:
© 2016
PY - 2017/4
Y1 - 2017/4
N2 - The present review analyzes various approaches for the design and synthesis of different nanoparticles for imaging and therapy. Nanoparticles for computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and optical imaging are discussed. The influence of nanoparticle size, shape, surface charge, composition, surface functionalization, active targeting and other factors on imaging and therapeutic efficacy is analyzed. Cyto- and genotoxicity of nanoparticles are also discussed. Special attention in the review is paid to the imaging of apoptotic tissues and cells in different diseases.
AB - The present review analyzes various approaches for the design and synthesis of different nanoparticles for imaging and therapy. Nanoparticles for computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and optical imaging are discussed. The influence of nanoparticle size, shape, surface charge, composition, surface functionalization, active targeting and other factors on imaging and therapeutic efficacy is analyzed. Cyto- and genotoxicity of nanoparticles are also discussed. Special attention in the review is paid to the imaging of apoptotic tissues and cells in different diseases.
KW - Apoptosis
KW - Computed tomography
KW - Magnetic resonance
KW - Nanoparticle
KW - Theranostic
UR - http://www.scopus.com/inward/record.url?scp=84996758789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84996758789&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2016.06.016
DO - 10.1016/j.addr.2016.06.016
M3 - Review article
C2 - 27374457
AN - SCOPUS:84996758789
SN - 0169-409X
VL - 113
SP - 122
EP - 140
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -