Nanoscale engineering of LDL-retentive substrates

E. Chnari, Prabhas Moghe

Research output: Contribution to journalConference article

Abstract

Atherosclerosis, the hardening of arteries due to build-up of lipoproteins, is one of the leading causes of death in the United States. Conventional therapies as well as purely pharmacological treatments have not been consistently effective and can entail severe side effects. Encouraging preliminary results from a novel approach have shown that design of nanocarriers with varying surface charge and geometry can lead to effective sequestration of LDL before it gets extensively oxidized and subsequent controlled LDL presentation to macrophages for enhanced uptake and clearance from the intima.

Original languageEnglish (US)
Pages (from-to)1656-1657
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Fingerprint

Lipoproteins
Macrophages
Surface charge
Hardening
Geometry
Substrates
Cause of Death
Atherosclerosis
Arteries
Pharmacology
oxidized low density lipoprotein
Therapeutics

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

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Nanoscale engineering of LDL-retentive substrates. / Chnari, E.; Moghe, Prabhas.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 2, 01.12.2002, p. 1656-1657.

Research output: Contribution to journalConference article

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AU - Moghe, Prabhas

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AB - Atherosclerosis, the hardening of arteries due to build-up of lipoproteins, is one of the leading causes of death in the United States. Conventional therapies as well as purely pharmacological treatments have not been consistently effective and can entail severe side effects. Encouraging preliminary results from a novel approach have shown that design of nanocarriers with varying surface charge and geometry can lead to effective sequestration of LDL before it gets extensively oxidized and subsequent controlled LDL presentation to macrophages for enhanced uptake and clearance from the intima.

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