Nanotechnology approaches for personalized treatment of multidrug resistant cancers

Tamara Minko, Lorna Rodriguez-Rodriguez, Vitaly Pozharov

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.

Original languageEnglish (US)
Pages (from-to)1880-1895
Number of pages16
JournalAdvanced Drug Delivery Reviews
Issue number13-14
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


  • Antibody
  • Antisense oligonucleotides
  • CD44
  • Cancer stem cells
  • Drug delivery system
  • LHRH
  • Passive and active targeting
  • Peptides
  • Pump and nonpump resistance
  • SiRNA


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