Nanotechnology approaches for personalized treatment of multidrug resistant cancers

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.

Original languageEnglish (US)
Pages (from-to)1880-1895
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number13-14
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Antibody
  • Antisense oligonucleotides
  • CD44
  • Cancer stem cells
  • Drug delivery system
  • LHRH
  • Passive and active targeting
  • Peptides
  • Pump and nonpump resistance
  • SiRNA

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