Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products

Robert J. Laumbach, Nancy Fiedler, Carol R. Gardner, Debra L. Laskin, Zhi Hua Fan, Junfeng Zhang, Charles J. Weschler, Paul J. Lioy, Robert B. Devlin, Pamela Ohman-Strickland, Kathie Kelly-McNeil, Howard M. Kipen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective: Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in "sick buildings," cause nasal irritation and inflammation under controlled exposure conditions. Methods: Healthy, nonsmoking women (n = 130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air "MA" control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m3 and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8. Results: We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions. Conclusions: Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations.

Original languageEnglish (US)
Pages (from-to)1182-1189
Number of pages8
JournalJournal of occupational and environmental medicine
Volume47
Issue number11
DOIs
StatePublished - Nov 2005

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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