Nasal toxicity of cocaine: a hypercoagulable effect?

R. Patel, R. Shah, S. Baredes, C. R. Spillert, E. J. Lazaro

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Nasal insufflation of cocaine injures the nasal mucosa and can perforate the septum. Cocaine-induced vasoconstriction resulting in ischemia is one of the methods that may be responsible for this damage. We are determining whether cocaine also produces a hypercoagulable state that may compound factors which have been previously established to cause damage to the nasal mucosa and septum. This study uses Modified Recalcification Time (MRT), a test developed in our laboratory that has the ability to measure the overall coagulation process. Our study revealed no connection between cocaine and enhanced platelet function or monocyte-released tissue factor. The coagulation process was unaffected by the addition of the drug, so we conclude that cocaine does not cause a hypercoagulable state and cannot assist in the explanation regarding the ischemic changes of the nasal septum.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalJournal of the National Medical Association
Issue number1
StatePublished - Jan 2000

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Nasal toxicity of cocaine: a hypercoagulable effect?'. Together they form a unique fingerprint.

Cite this