Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2

Edmund C. Lattime, Michael J. Bykowsky, Osias Stutman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The studies described in this report demonstrate that NC activity is the function of a number of distinct effector cell populations and not due to a single type of NC cell. While IL-2 was found to augment the NC activity of all populations tested, in vitro culture and T-deficient mutant mouse studies would suggest that it is not necessary for maintaining NC activity. With NC being an 'activity' rather than the function of a single effector cell type, identifying all populations that lyse the WEHI-164 target as a single type of effector is no longer valid. As discussed previously, the same situation may apply to the NK compartment [43].

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalImmunologic Research
Issue number1
StatePublished - Mar 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology

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