Natural protection against HIV-1 infection provided by HIV-2

Karin Travers; Souleymane Mboup; Richard Marlink; Aissatou Guèye-Ndiaye; Tidiane Siby; Ibou Thior; Ibrahima Traore; Abdoulaye Dieng-Sarr; Jean Louis Sankalé; Christopher Mullins; Ibrahima Ndoye; Chung Cheng Hsieh; Max Essex; Phyllis Kanki

doi:10.1126/science.7539936

Natural protection against HIV-1 infection provided by HIV-2

Karin Travers, Souleymane Mboup, Richard Marlink, Aissatou Guèye-Ndiaye, Tidiane Siby, Ibou Thior, Ibrahima Traore, Abdoulaye Dieng-Sarr, Jean Louis Sankalé, Christopher Mullins, Ibrahima Ndoye, Chung Cheng Hsieh, Max Essex, Phyllis Kanki

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172 Scopus citations

Abstract

Significant differences have been observed in the rates of transmission and disease development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2-infected people remain asymptomatic for prolonged periods, the hypothesis that HIV-2 might protect against subsequent infection by HIV-1 was considered. During a 9-year period in Dakar, Senegal, the seroincidence of both HIV types was measured in a cohort of commercial sex workers. Despite a higher incidence of other sexually transmitted diseases (STDs), HIV-2-infected women had a lower incidence of HIV-1 than did HIV-seronegative women, with a relative risk of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms involved may be directly relevant to HIV-1 vaccine development.

Original language	English (US)
Pages (from-to)	1612-1615
Number of pages	4
Journal	Science
Volume	268
Issue number	5217
DOIs	https://doi.org/10.1126/science.7539936
State	Published - 1995
Externally published	Yes

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title = "Natural protection against HIV-1 infection provided by HIV-2",

abstract = "Significant differences have been observed in the rates of transmission and disease development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2-infected people remain asymptomatic for prolonged periods, the hypothesis that HIV-2 might protect against subsequent infection by HIV-1 was considered. During a 9-year period in Dakar, Senegal, the seroincidence of both HIV types was measured in a cohort of commercial sex workers. Despite a higher incidence of other sexually transmitted diseases (STDs), HIV-2-infected women had a lower incidence of HIV-1 than did HIV-seronegative women, with a relative risk of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms involved may be directly relevant to HIV-1 vaccine development.",

author = "Karin Travers and Souleymane Mboup and Richard Marlink and Aissatou Gu{\`e}ye-Ndiaye and Tidiane Siby and Ibou Thior and Ibrahima Traore and Abdoulaye Dieng-Sarr and Sankal{\'e}, {Jean Louis} and Christopher Mullins and Ibrahima Ndoye and Hsieh, {Chung Cheng} and Max Essex and Phyllis Kanki",

year = "1995",

doi = "10.1126/science.7539936",

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volume = "268",

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publisher = "American Association for the Advancement of Science",

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T1 - Natural protection against HIV-1 infection provided by HIV-2

AU - Travers, Karin

AU - Mboup, Souleymane

AU - Marlink, Richard

AU - Guèye-Ndiaye, Aissatou

AU - Siby, Tidiane

AU - Thior, Ibou

AU - Traore, Ibrahima

AU - Dieng-Sarr, Abdoulaye

AU - Sankalé, Jean Louis

AU - Mullins, Christopher

AU - Ndoye, Ibrahima

AU - Hsieh, Chung Cheng

AU - Essex, Max

AU - Kanki, Phyllis

PY - 1995

Y1 - 1995

N2 - Significant differences have been observed in the rates of transmission and disease development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2-infected people remain asymptomatic for prolonged periods, the hypothesis that HIV-2 might protect against subsequent infection by HIV-1 was considered. During a 9-year period in Dakar, Senegal, the seroincidence of both HIV types was measured in a cohort of commercial sex workers. Despite a higher incidence of other sexually transmitted diseases (STDs), HIV-2-infected women had a lower incidence of HIV-1 than did HIV-seronegative women, with a relative risk of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms involved may be directly relevant to HIV-1 vaccine development.

AB - Significant differences have been observed in the rates of transmission and disease development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2-infected people remain asymptomatic for prolonged periods, the hypothesis that HIV-2 might protect against subsequent infection by HIV-1 was considered. During a 9-year period in Dakar, Senegal, the seroincidence of both HIV types was measured in a cohort of commercial sex workers. Despite a higher incidence of other sexually transmitted diseases (STDs), HIV-2-infected women had a lower incidence of HIV-1 than did HIV-seronegative women, with a relative risk of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms involved may be directly relevant to HIV-1 vaccine development.

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JF - Science

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Natural protection against HIV-1 infection provided by HIV-2

Abstract

All Science Journal Classification (ASJC) codes

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