Natural protection against HIV-1 infection provided by HIV-2

Karin Travers, Souleymane Mboup, Richard Marlink, Aissatou Guèye-Ndiaye, Tidiane Siby, Ibou Thior, Ibrahima Traore, Abdoulaye Dieng-Sarr, Jean Louis Sankalé, Christopher Mullins, Ibrahima Ndoye, Chung Cheng Hsieh, Max Essex, Phyllis Kanki

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


Significant differences have been observed in the rates of transmission and disease development in human immunodeficiency virus (HIV) types 1 and 2. Because many HIV-2-infected people remain asymptomatic for prolonged periods, the hypothesis that HIV-2 might protect against subsequent infection by HIV-1 was considered. During a 9-year period in Dakar, Senegal, the seroincidence of both HIV types was measured in a cohort of commercial sex workers. Despite a higher incidence of other sexually transmitted diseases (STDs), HIV-2-infected women had a lower incidence of HIV-1 than did HIV-seronegative women, with a relative risk of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms involved may be directly relevant to HIV-1 vaccine development.

Original languageEnglish (US)
Pages (from-to)1612-1615
Number of pages4
Issue number5217
StatePublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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