Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum

Zhengang Yang, Yan You, Steven W. Levison

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Ischemia-induced striatal neurogenesis from progenitors in the adjacent subventricular zone (SVZ) in young and adult rodents has been reported. However, it has not been established whether the precursors that reside in the SVZ retain the capacity to produce the full range of striatal neurons that has been destroyed. By using a neonatal rat model of hypoxic/ischemic brain damage, we show here that virtually all of the newly produced striatal neurons are calretinin (CR)-immunoreactive (+), but not DARPP-32+, calbindin-D-28K+ parvalbumin+, somatostatin+, or choline acetyltransferase+. Retroviral fate-mapping studies confirm that these newly born CR+ neurons are indeed descendants of the SVZ. Our studies indicate that, although the postnatal SVZ has the capacity to produce a range of neurons, only a subset of this repertoire is manifested in the brain after injury.

Original languageEnglish (US)
Pages (from-to)19-33
Number of pages15
JournalJournal of Comparative Neurology
Volume511
Issue number1
DOIs
StatePublished - Nov 1 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Calretinin
  • Medium spiny neurons
  • Neural stem cells
  • Neurogenesis
  • Stroke
  • Subventricular zone

Fingerprint Dive into the research topics of 'Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum'. Together they form a unique fingerprint.

Cite this