Networks, biology and systems engineering: A case study in inflammation

P. T. Foteinou, E. Yang, I. P. Androulakis

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Biological systems can be modeled as networks of interacting components across multiple scales. A central problem in computational systems biology is to identify those critical components and the rules that define their interactions and give rise to the emergent behavior of a host response. In this paper we will discuss two fundamental problems related to the construction of transcription factor networks and the identification of networks of functional modules describing disease progression. We focus on inflammation as a key physiological response of clinical and translational importance.

Original languageEnglish (US)
Pages (from-to)2028-2041
Number of pages14
JournalComputers and Chemical Engineering
Volume33
Issue number12
DOIs
StatePublished - Dec 10 2009

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

Keywords

  • Disease models
  • Inflammation
  • Systems biology
  • Transcriptional regulation

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