Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice

Susan S. Kim, Hansen Wang, Xiang Yao Li, Tao Chen, Valentina Mercaldo, Giannina Descalzi, Long-Jun Wu, Min Zhuo

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Affective disorders, which include anxiety and depression, are highly prevalent and have overwhelming emotional and physical symptoms. Despite human brain imaging studies, which have implicated the prefrontal cortex including the anterior cingulate cortex (ACC), little is known about the ACC in anxiety disorders. Here we show that the ACC does modulate anxiety-like behavior in adult mice, and have identified a protein that is critical for this modulation. Absence of neurabin, a cytoskeletal protein, resulted in reduced anxiety-like behavior and increased depression-like behavior. Selective inhibition of neurabin in the ACC reproduced the anxiety but not the depression phenotype. Furthermore, loss of neurabin increased the presynaptic release of glutamate and cingulate neuronal excitability. These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders.

Original languageEnglish (US)
Article number6
JournalMolecular brain
Volume4
Issue number1
DOIs
StatePublished - Jan 21 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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