Neural cell adhesion molecule (NCAM-/-) null mice show impaired sensitization of the startle response

C. F. Plappert, Melitta Camartin, P. K.D. Pilz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The neural cell adhesion molecule (NCAM) plays important roles in development of the nervous system and in synaptic plasticity and memory formation in the adult. The present study sought to further investigate the role of NCAM in learning by testing habituation and footshock sensitization learning of the startle response (SR) in NCAM null mutant (NCAM-/-) and wildtype littermate (NCAM +/+) mice. Whereas habituation is a form of non-associative learning, footshock sensitization is induced by rapid contextual fear conditioning. Habituation was tested by repetitive presentation of acoustic and tactile startle stimuli. Although NCAM-/- mice showed differences in sensitivity in both stimulus modalities, habituation learning was intact in NCAM-/- mice, suggesting that NCAM does not play a role in the mechanisms underlying synaptic plasticity in the startle pathway. Footshock sensitization was elicited by presentation of electric footshocks between two series of acoustic stimuli. In contrast to habituation, footshock sensitization learning was attenuated in NCAM-/- mice: the acoustic SR increase after the footshocks was lower in the mutant than in wildtype mice, indicating that NCAM plays an important role in the relevant brain areas, such as amygdala and/or the hippocampus.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalGenes, Brain and Behavior
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Startle Reflex
Neural Cell Adhesion Molecules
Learning
Acoustics
Neuronal Plasticity
Touch
Amygdala
Nervous System
Fear
Hippocampus

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Keywords

  • Acoustic startle
  • Gene ablation
  • Habituation
  • Learning
  • Memory
  • Mouse
  • NCAM
  • Sensitization
  • Tactile

Cite this

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abstract = "The neural cell adhesion molecule (NCAM) plays important roles in development of the nervous system and in synaptic plasticity and memory formation in the adult. The present study sought to further investigate the role of NCAM in learning by testing habituation and footshock sensitization learning of the startle response (SR) in NCAM null mutant (NCAM-/-) and wildtype littermate (NCAM +/+) mice. Whereas habituation is a form of non-associative learning, footshock sensitization is induced by rapid contextual fear conditioning. Habituation was tested by repetitive presentation of acoustic and tactile startle stimuli. Although NCAM-/- mice showed differences in sensitivity in both stimulus modalities, habituation learning was intact in NCAM-/- mice, suggesting that NCAM does not play a role in the mechanisms underlying synaptic plasticity in the startle pathway. Footshock sensitization was elicited by presentation of electric footshocks between two series of acoustic stimuli. In contrast to habituation, footshock sensitization learning was attenuated in NCAM-/- mice: the acoustic SR increase after the footshocks was lower in the mutant than in wildtype mice, indicating that NCAM plays an important role in the relevant brain areas, such as amygdala and/or the hippocampus.",
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Neural cell adhesion molecule (NCAM-/-) null mice show impaired sensitization of the startle response. / Plappert, C. F.; Camartin, Melitta; Pilz, P. K.D.

In: Genes, Brain and Behavior, Vol. 5, No. 1, 01.01.2006, p. 46-52.

Research output: Contribution to journalArticle

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