Neurite outgrowth and growth cone morphology on micropatterned surfaces

Hsin Chien Tai, Helen M. Buettner

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The quantitative effects of micropatterned laminin surfaces on neurite outgrowth and growth cone morphology were investigated. Using microlithography, 20- or 30-μmwide laminin stripes were applied to the surface of a glass coverslip, alternating with BSA-coated glass stripes of the same dimension. Growth on these surfaces was strongly biased in the direction parallel to the stripes, but the mean length of outgrowth was reduced relative to that on uniform laminin surfaces. Growth cones were slightly more elongated on micropatterned surfaces than on controls and were aligned with the pattern. These results provide a starting point for examining the fundamental effects of micropatterned surfaces on neurite outgrowth and ways in which these may be useful in controlling and guiding neurite outgrowth for biotechnological applications.

Original languageEnglish (US)
Pages (from-to)364-370
Number of pages7
JournalBiotechnology Progress
Volume14
Issue number3
DOIs
StatePublished - May 1998

All Science Journal Classification (ASJC) codes

  • Biotechnology

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